Prof. Dr. Adriaan J. Minnaard
Head of the department of Chemical Biology
Stratingh Institute for Chemistry
Nijenborgh 7, 9747 AG Groningen
University of Groningen, The Netherlands
A.J.Minnaard@rug.nl
Director of the Stratingh Institute for Chemistry
Master degree
| University: | “Molecular Sciences” at the Agricultural University Wageningen, The Netherlands |
Doctorate
| University: | Agricultural University Wageningen, The Netherlands |
| Date (dd/mm/yy): | 1997 (cum laude) |
| Supervisor (‘Promotor’): | Prof. Dr. Ae. de Groot |
| Co-promotor: | Dr. J.B.P.A. Wijnberg |
| Title of thesis: | Germacrane Sesquiterpenes; Synthesis and Role in Biosynthesis |
Career since graduation
| 1997 – 1999 | Researcher at DSM-Research in Geleen. |
| 1999 _ 2005 | Assistant Professor at the Stratingh Institute for Chemistry, University of Groningen, in the department of Synthetic Organic Chemistry headed by Prof. Dr. B.L. Feringa |
| 2006 –2009 | Associate Professor in Bio-Organic Chemistry, Stratingh Institute for Chemistry. |
| 2006 – 2007 | Guest Professor at the Max Planck Institute for Molecular Physiology, Dortmund, Germany, in the Chemical Biology group of Prof. Dr. H. Waldmann. |
| 2007 – | Head of the department of Bio-organic Chemistry, Stratingh institute for Chemistry. |
| 2009 – | Full Professor in Bio-organic Chemistry, head of the department of Chemical Biology |
| 2016 – | Director of the Stratingh Institute for Chemistry |
National and international outreach
| 1987 | Member of the Royal Dutch Chemical Society |
| 1991 | Master degree Cum Laude (with Honors) |
| 1992 | Ph.D. Scholarship at Wageningen Agricultural University |
| 1997 | Ph.D. degree Cum Laude (with Honors) |
| 1999 | Member of the American Chemical Society |
| 2000 | Member of the Dutch Science Foundation Study groups Design and Synthesis, Coordination Chemistry and Homogeneous Catalysis, and Biomolecular Chemistry |
| 2001 | Member of the scientific board of the Twelfth European Symposium on Organic Synthesis. |
| 2002 | Member of the scientific board of the International Chemistry Olympiad 2002 |
| 2002 | Member of the European COST network D21 and D24 on asymmetric catalysis. |
| 2005 | Member of the board of the Backerfonds (foundation that promotes Organic Chemistry in The Netherlands) |
| 2006 | Member of the board of the Netherlands Institute for Catalysis Research (NIOK) |
| 2007 | Member of the organizing committee of the 11th international Conference on Circular Dichroism |
| 2007 | Member of the German Chemical Society (GDCh) |
| 2008 | Member of the board of the Stratingh Institute for Chemistry (University of Groningen) |
| 2008 | Associate member of the Zernike Institute of Advanced Materials (University of Groningen) |
| 2008 | Member of the Top-Research School NRSC-Catalysis |
| 2008 | Member of the International Advisory Board of the European Journal of Organic Chemistry |
| 2010 | Chairman of the Dutch Science Foundation Study group Design and Synthesis |
| 2011 | Member of the International Advisory Board of the Asian Journal of Organic Chemistry |
| 2012 | Chairman of the board of the Stratingh Institute for Chemistry (University of Groningen) |
| 2012 | Director of Teaching, Chemistry & Chemical Technology (University of Groningen) |
| 2013 | Member of the Advisory board of the HRSMC Summer school, New Vistas in Organic Synthesis |
| 2013 | Associate member of the Groningen Institute of Biology and Biotechnology (University of Groningen) |
| 2013 | Member of the Scientific Advisory Board of the twelfth European Symposium on Organic Chemistry |
| 2014 | Member of the Scientific Advisory Board of the Lorentz Center (International Center for Workshops in the Sciences) |
| 2016 | Director of the Stratingh Institute for Chemistry |
Publications
- Contributions to books: 5
- Patents: 5
- papers in international refereed journals: 253, see publication list,
- h-index = 54.
Minnaard is scientific advisor of the companies AgileBiotics and KE-Instruments
15 of the main publications of Minnaard as corresponding author since 2012:
1. Wan, I. C., Witte, M. D., Minnaard, A. J. 2017 ‘Site-selective carbon-carbon bond formation in unprotected monosaccharides using photoredox catalysis’ Chemical Communications, vol 53, no. 36, pp. 4926-4929.
2. Buter, J.; Heijnen, D.; Vila, C.; Hornillos, V.; Otten, E.; Giannerini, M.; Minnaard, A. J.; Feringa, B. L. Palladium-Catalyzed, tert-Butyllithium-Mediated Dimerization of Aryl Halides and Its Application in the Atropselective Total Synthesis of Mastigophorene A. Angew. Chem. Int. Ed. 2016, 55, 3620-3624.
3. Armenise, N.; Tahiri, N.; Eisink, N.N.H.M.; Denis, M.; Jager, M.; De Vries, J.G.; Witte, M.D.; Minnaard, A.J. Deuteration enhances catalyst lifetime in palladium-catalysed alcohol oxidation Chem. Comm. 2016, 52, 2189-2191.
4. Jäger, M.; Minnaard, A.J. Regioselective modification of unprotected glycosides. Chem. Comm. 2016, 52, 656-664.
5. Geerdink, D.; Minnaard, A. J. Total synthesis of Sulfolipid-1. Chem. Comm. 2014, 50, 2286-2288.
6. Wu, Z.; Harutyunyan, S. R.; Minnaard, A. J. Total Synthesis of (R,R,R)-γ-Tocopherol through Cu-Catalyzed Asymmetric 1,2-Addition. Chem. Eur. J. 2014, 20, 14250-14255.
7. Fodran, P.; Minnaard, A.J. Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor. Org. Biomol. Chem. 2013, 11, 6919-6928.
8. Jaeger, M.; Hartmann, M.; de Vries, J.G.; Minnaard, A.J. Catalytic Regioselective Oxidation of Glycosides. Angew. Chem., Int. Ed. 2013, 52, 7809-7812.
9. Kortmann, F. A.; Chang, M.-C.; Otten, E.; Couzijn, E. P. A.; Lutz, M.; Minnaard, A. J. Consecutive dynamic resolutions of phosphine oxides. Chem. Science 2014, 5, 1322-1327.
10. Wu, Z.; Harutyunyan, S. R.; Minnaard, A. J. Total Synthesis of (R,R,R)-γ-Tocopherol through Cu-Catalyzed Asymmetric 1,2-Addition. Chem. Eur. J. 2014, 20, 14250-14255.
11. Geerdink, D.; ter Horst, B.; Lepore, M.; Mori, L.; Puzo, G.; Hirsch, A.K.H.; Gilleron, M.; de Libero, G.; Minnaard A.J. Total synthesis, stereochemical elucidation and biological evaluation of Ac2SGL; a 1,3-methyl branched sulfoglycolipid from Mycobacterium tuberculosis. Chem. Sci. 2013, 4, 709-716.
12. Matcha, K.; Madduri, A. V. R.; Roy, S.; Ziegler, S.; Waldmann, H.; Hirsch, A. K. H.; Minnaard, A.J. Total Synthesis of (-)-Doliculide, Structure-Activity Relationship Studies and Its Binding to F-Actin. ChemBioChem 2012, 13, 2537-2548.
13. Barroso, S.; Castelli, R.; Baggelaar, M.P.; Geerdink, D.; ter Horst, B.; Casas-Arce, E.; Overkleeft, H. S.; van der Marel, G. A.; Codee, J. D. C.; Minnaard A. J. Total Synthesis of the Triglycosyl Phenolic Glycolipid PGL-tb1 from Mycobacterium tuberculosis. Angew. Chem., Int. Ed. 2012, 51, 11774-11777.
14. Madduri, A.V. R.; Harutyunyan, S. R.; Minnaard, A. J. Asymmetric Copper-Catalyzed Addition of Grignard Reagents to Aryl Alkyl Ketones. Angew. Chem., Int. Ed. 2012, 51, 3164-3167.
15. Buter, J.; Moezelaar, R.; Minnaard, A. J. Enantioselective palladium catalyzed conjugate additions of ortho-substituted arylboronic acids to β,β-disubstituted cyclic enones: total synthesis of herbertenediol, enokipodin A and enokipodin B. Org. Biomol. Chem. 2014, 12, 5883-5890.